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HPV prevalence and genotyping in the cervix of Chinese women
Shao-Ming WANG, Jing LI, You-Lin QIAO
《医学前沿(英文)》 2010年 第4卷 第3期 页码 259-263 doi: 10.1007/s11684-010-0095-5
关键词: human papillomavirus (HPV) genotyping cervical cancer precancerous lesions Chinese women
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 138-142 doi: 10.1007/s11684-013-0247-5
It has been demonstrated that single nucleotide polymorphisms (SNPs) of SIPA1 (signal-induced proliferation associated gene 1) are associated with metastatic efficiency in both human and rodents. The purpose of this study was to determine whether SIPA1 545 C>T polymorphism was associated with overall survival in patients with metastatic breast cancer. In this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patients using polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). Survival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-Meier method with log-rank tests. We found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185 patients with metastatic breast cancer. Patients with SIPA1545 T/T genotype had a significantly worse overall survival (OS) than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). Moreover, in multivariate analysis, as compared with the C/C or C/T genotype, the T/T genotype remained an independent unfavorable prognostic marker of OS in this cohort (hazard ratio [HR] = 2.16; 95% CI= 1.12–4.15; P = 0.022). Our findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have a poorer survival compared to patients with C/C or C/T genotype.
A survey of physical activity among urban women in China
Shilin DENG MD, Tongyuan LIU,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 463-469 doi: 10.1007/s11684-009-0081-y
Effects and mechanisms of acupuncture on women related health
《医学前沿(英文)》 doi: 10.1007/s11684-023-1051-5
Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li
《医学前沿(英文)》 2018年 第12卷 第5期 页码 509-517 doi: 10.1007/s11684-017-0554-3
This study was performed to evaluate the oncological and reproductive outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarian tumors in China. One hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000 and August 31, 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5%, whereas overall survival (OS) was 93.9%. Univariate analysis suggested that delivery after treatment is related to PFS (P=0.023), whereas histology significantly influenced OS. Cox regression analysis suggested that only histology was associated with PFS and OS (P<0.05). Among the 129 women who completed adjuvant chemotherapy (ACT), none developed amenorrhea. Among the 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestations including 35 live births without birth defects. Non-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy. Histology might be the only independent prognostic factor for PFS and OS. FSS followed by ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase the PFS or OS. Use of gonadotropin-releasing hormone agonist was not beneficial for fertility.
关键词: malignant germ cell tumors ovarian sex cord-stromal tumors fertility-sparing surgery prognosis fertility
《环境科学与工程前沿(英文)》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1628-x
● Metabolome can distinguish pregnant women exposure to PFOA at different degrees.
关键词: Perfluorooctanoic acid Exposure Pregnant women Metabolomic GSH Microbiota metabolism
Shilin DENG MD ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 323-329 doi: 10.1007/s11684-009-0061-2
关键词: early postmenopausal women bone mineral density exercise effects
沙吾力·艾力卡,王晓军,艾比拜·买买提明
《中国工程科学》 2014年 第16卷 第5期 页码 60-62
本文旨在了解新疆人体免疫缺陷病毒(HIV)感染孕产妇的婚育状况,从而为在感染孕产妇中开展生殖健康教育提供依据,笔者利用2010—2012 年间在预防艾滋病母婴传播管理信息网络直报系统中报告的HIV感染孕产妇个案卡资料进行分析。结果显示:1 692 例感染孕产妇平均年龄为29.03 岁,其中20~29岁的小年龄组孕产妇占53.31 %;传播途径为性传播的占60.52 %;婚姻状况初婚者占多数,但再婚者占一定比例(36.40 %);两次及以上妊娠者占70.69 %,最多达10 次,但有两次及以上分娩经历者占19.92 %。由此可以看出,新疆HIV感染孕产妇中再婚比例明显高于全国其他省(自治区),终止妊娠者占一定比例,因此在女性感染者中有针对性地开展生殖健康教育活动势在必行。
景秀,杨继高,刘俊,张丽华
《中国工程科学》 2014年 第16卷 第5期 页码 105-109
为了探索影响农村绝经后妇女性生活满意度的因素,从而为开展老年妇女保健提供科学依据,笔者于2012 年3—8 月采用多阶段随机抽样方法对重庆市5 个区县农村绝经后妇女采用统一方法进行问卷调查和体检。结果显示,重庆市农村绝经后妇女对目前性生活满意和不满意的分别占83.7 %和16.3 %。单因素分析显示,绝经后妇女性生活满意度与其婚姻状况、文化程度、家庭收入、家庭结构、是否患有妇科疾病、最近两周是否有生殖道不适、起居方式、是否需要性生活、性生活频率、老年性保健知识、自觉体力状态及自觉生活状态等12 个变量有关(P<0.05);多因素Logistic 回归分析显示,分居方式(比值比(OR)=1.711,95 %置信区间(CI)为1.334~2.194)、性生活频率高(OR=1.694,95 % CI 为1.334~2.152)、自觉体力状态差(OR=1.281,95 % CI 为1.018~1.613)是危险因素,家庭收入高(OR=0.651,95 % CI 为0.512~0.826)和既往有妇科疾病(OR=0.689,95 % CI 为0.486~0.977)是保护因素。因此,农村存在多种影响绝经后妇女性生活满意度的相关因素,应重视对绝经后妇女的性教育,改善她们的生活质量。
关键词: 绝经后妇女 性生活满意度 影响因素 Logistic分析
Epidemiological studies of women under age 30 infected with human papillomavirus
Zhihua LIU MD, Qing LI BM, Weihong LI BM,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 459-462 doi: 10.1007/s11684-009-0084-8
关键词: cervical cancer human papilloma virus cervical intraepithelial neoplasia
秦丽艳
《中国工程科学》 2015年 第17卷 第6期 页码 53-56
通过对天津滨海新区产后妇女对避孕相关问题的认知现状的调查分析,以期认识到提高产后妇女的整体避孕意识的必要性。采用自行设计问卷,由固定医师进行询问并填写问卷。产后妇女中81.9 %的人知道产后应该避孕,但只有46.9 %知道产后高危人工流产的危害,48.8 %的产后妇女没有避孕计划或打算3个月后再采取避孕措施,47.2 %的产后妇女计划或已于首次性生活采取避孕措施,其中学历高、职业为干部组、剖宫产的产后妇女避孕意识较好,258人(80.6 %)通过住院分娩或产后访视得知产后应避孕,207人(64.7 %)在产后避孕方法上首选避孕套。产后妇女选择长效可靠避孕措施的少,医护工作者应提高对产后妇女有关产后避孕的指导和宣传,提高产后妇女对避孕效果可靠措施的使用率,提高产后妇女的生活质量。
关键词: 产后妇女;避孕;人工流产
沙吾力·艾力卡,艾比拜·买买提明,王晓军
《中国工程科学》 2015年 第17卷 第6期 页码 50-52
旨在了解新疆HIV感染孕产妇妊娠结局 。利用2010—2013年间在预防艾滋病母婴传播管理信息网络直报系统中报告的HIV感染孕产妇个案卡资料进行分析。2 256例HIV感染孕产妇平均年龄29.1岁,以维吾尔族为主,占90.65 %,初中及以下文化程度者占72.07 %,无业和农民占82.36 %(其中无业者占47.30 %),初婚占56.12 %,再婚占37.19 %。2次及以上妊娠者占69.68 %,有316例HIV感染孕产妇在知道自己的感染状况后仍然选择妊娠,占总数的14.01 %;再次妊娠的HIV感染孕产妇中人工终止妊娠的比例明显高于第一次接受服务的HIV感染孕产妇,两者有统计学差异(χ2=141.14,P=0.000)。新疆HIV感染孕产妇知道自身感染情况后仍有选择再次妊娠者,再次妊娠者中选择人工终止妊娠的比例明显高于第一次妊娠者,提示意外妊娠的存在,建议加强HIV感染妇女预防艾滋病母婴传播咨询服务和避孕指导,减少意外妊娠的发生,使HIV感染女性能够了解相关知识从而能够做出正确的生育或妊娠选择。
沈洁,高丽丽,潘迎
《中国工程科学》 2014年 第16卷 第5期 页码 16-19
为了了解北京市剖宫产术后妇女的避孕意愿及其影响因素,在北京市城、近、郊区采用分层整群抽样方法随机抽取2011 年7 月—2011 年12 月期间接受剖宫产手术的产妇364 名,进行问卷调查。采用卡方检验和多因素Logistic 回归方法对问卷调查结果进行分析。结果显示,被调查妇女平均年龄为(31±4.53)岁,剖宫产术后计划恢复性生活时间中位数为7 周。96.43 %的妇女对于产后可以采用的避孕方法并不清楚。仅有27.74 %的妇女表示产后会尽早或立即采取避孕措施,避孕套是妇女首选的产后避孕方法,占75.27 %。72.25 %的妇女没有避孕计划或要等到产后3 个月才开始避孕。62.64 %的妇女在剖宫产术后接受了避孕指导,医生推荐的产后避孕方法中避孕套占首位。医生强调剖宫产术后避孕的重要性、妇女具备正确产后避孕知识是妇女剖宫产术后尽早开始避孕的保护因素。剖宫产妇女对产后避孕服务有较高需求,希望在产前保健或产后访视时能得到专业人员的产后避孕咨询指导。剖宫产术后再次妊娠存在健康风险,剖宫产妇女产后尽早落实避孕措施应引起高度关注。建议尽快针对剖宫产妇女开展产后避孕服务,摸索适合北京的服务模式,以满足需求,减少产后非意愿妊娠的发生,降低剖宫产术后人工流产的风险。
Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin
《医学前沿(英文)》 2018年 第12卷 第5期 页码 518-524 doi: 10.1007/s11684-017-0575-y
The increased levels of intracellular reactive oxygen species (ROS) in granulosa cells (GCs) may affect the pregnancy results in women with polycystic ovary syndrome (PCOS). In this study, we compared thein vitro fertilization and embryo transfer (IVF-ET) results of 22 patients with PCOS and 25 patients with tubal factor infertility and detected the ROS levels in the GCs of these two groups. Results showed that the PCOS group had significantly larger follicles on the administration day for human chorionic gonadotropin than the tubal factor group (P<0.05); however, the number of retrieved oocytes was not significantly different between the two groups (P>0.05). PCOS group had slightly lower fertilization, cleavage, grade I/II embryo, clinical pregnancy, and implantation rates and higher miscarriage rate than the tubal factor group (P>0.05). We further found a significantly higher ROS level of GCs in the PCOS group than in the tubal factor group (P<0.05). The increased ROS levels in GCs caused GC apoptosis, whereas NADPH oxidase 2 (NOX2) specific inhibitors (diphenyleneiodonium and apocynin) significantly reduced the ROS production in the PCOS group. In conclusion, the increased ROS expression levels in PCOS GCs greatly induced cell apoptosis, which further affected the oocyte quality and reduced the positive IVF-ET pregnancy results of women with PCOS. NADPH oxidase pathway may be involved in the mechanism of ROS production in GCs of women with PCOS.
张君娴,杨婷,徐晓帆,龙春燕,刘建苏,李莉
《中国工程科学》 2015年 第17卷 第6期 页码 57-60
了解乌鲁木齐市流动育龄妇女的避孕状况,为今后开展避孕方法知情选择优质服务提供参考。采用分层-整群-随机抽样的方法,对18~50岁符合条件的对象进行问卷调查,主要包括人口学特征、避孕措施的使用情况等。采用卡方检验和多因素Logistic回归方法进行统计分析。本次调查的106 568例流动育龄妇女中,避孕方法使用比例为92.78 %,避孕方法的选择依次为宫内节育器(65.74 %)、药物(23.17 %,包括口服避孕药、皮下埋植剂、避孕针等含药避孕方法)、避孕套(9.06 %)、绝育术(2.03 %)。多因素Logistic回归分析显示民族、学历、职业、婚姻状况和性生活频率对避孕方法的使用有影响。应根据不同民族的情况和流动育龄妇女的人口学特征,提供有针对性和个性化的避孕方法知情选择指导和服务。
标题 作者 时间 类型 操作
HPV prevalence and genotyping in the cervix of Chinese women
Shao-Ming WANG, Jing LI, You-Lin QIAO
期刊论文
Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer
null
期刊论文
Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safelyand successfully become pregnant---a Chinese retrospective cohort study among 148 cases
Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li
期刊论文
Untargeted metabolomic analysis of pregnant women exposure to perfluorooctanoic acid at different degrees
期刊论文
Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial
Shilin DENG MD ,
期刊论文
Epidemiological studies of women under age 30 infected with human papillomavirus
Zhihua LIU MD, Qing LI BM, Weihong LI BM,
期刊论文
Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with
Qiaohong Lai, Wenpei Xiang, Qing Li, Hanwang Zhang, Yufeng Li, Guijin Zhu, Chengliang Xiong, Lei Jin
期刊论文